Esketamine treatment

Esketamine Treatment: A Game-Changer for Mental Health

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Mental health treatment has come a long way with the development of new and innovative methods to alleviate symptoms. One of those methods is Esketamine treatment, which has been making waves in the world of mental health as a game-changer for individuals with treatment-resistant depression. 

In this blog post, we will closely examine what Esketamine is and its history. We will also explore the role of Esketamine in mental health treatment, including its impact on suicide risk and cognitive functioning. So, keep reading if this is something you may be interested in trying out.

Understanding Esketamine

Esketamine nasal spray, a game-changing innovation in mental health treatment, has shown remarkable efficacy in clinical trials. Acting on glutamate receptors, it specifically targets depression symptoms. Approved by the FDA for use in major depressive disorder, this newly initiated intranasal antidepressant option offers hope to patients. With Esketamine administration, stable remission becomes achievable, leading to improved outcomes. The drug’s impact on neurotransmitters like norepinephrine and dopamine is crucial to its effectiveness.

The History of Esketamine

Esketamine nasal spray, developed by Janssen, a subsidiary of Johnson & Johnson, gained FDA approval in 2019. This marked a significant milestone in mental health treatment as it offered a new approach to depression treatment by targeting glutamate receptors. The approval was based on clinical trial data demonstrating its efficacy. Since its approval, Esketamine nasal spray has been used in clinical practice and has shown promising results. 

The Role of Esketamine in Mental Health Treatment

There are many treatments out there available for mental health concerns like depression, and an Esketamine treatment is just one of those options. If you are interested in trying this, it is crucial to understand how it works and who it is most suitable for. Here are some essential details you should understand when deciding if this is the right fit for you.

Esketamine and Treatment-Resistant Depression

Esketamine nasal spray has demonstrated its effectiveness in clinical trials for treatment-resistant depression. This alternative treatment option has the potential to achieve remission in patients who have not responded to oral antidepressants. By targeting norepinephrine and dopamine receptors, it works differently than traditional oral antidepressants, potentially providing stability and improved well-being for those with treatment-resistant depression.

Esketamine’s Impact on Suicide Risk

Clinical trials have shown the efficacy of Esketamine nasal spray in reducing suicidal suicidal thoughts, offering new hope for individuals at risk of suicide. Furthermore, Esketamine nasal spray may help mitigate suicide risk in patients with major depressive disorder, providing an additional tool for mental health professionals in suicide prevention. This promising treatment option not only addresses depressive symptoms but also targets the critical issue of suicide, making Esketamine a game-changer in mental health care.

Cognitive Functioning and Esketamine

Clinical trial data has shown that administering Esketamine nasal spray does not impair cognitive performance. In fact, it has been observed that this Esketamine treatment preserves cognitive abilities while providing relief from depressive symptoms. This is significant because many patients are hesitant to undergo treatment for mental health issues due to concerns about potential cognitive side effects. 

Efficacy and Safety of an Esketamine Treatment

The efficacy and safety of Esketamine has been well-established in clinical practice. It has demonstrated significant effectiveness in providing stable response and remission in patients with mental health conditions. Because of this, clinical trial data supports its safety profile, making it a reliable and evidence-based treatment option. 

Esketamine nasal spray has demonstrated significant and rapid short-term and long-term remission effects for some patients. Helping individuals achieve a stable response effectively reduces the severity of depressive symptoms. Furthermore, Esketamine administration can lead to significant improvements in mental health outcomes, offering hope for those who have not responded well to traditional treatments. 

Current Limitations in Esketamine Treatment

While Esketamine treatment has shown promising results for mental health, certain limitations need to be considered. The administration of Esketamine requires a thorough risk evaluation due to its potential adverse effects, including dissociation and hallucinations. Clinical trials have used a placebo nasal spray as a control group to ensure accurate evaluation. 

The FDA and European Medicines Agency labels also include safety precautions to mitigate any risks associated with Esketamine administration. Clinical practice guidelines have also been established to ensure it’s used appropriately.

Frequently Asked Questions

What are some mental health conditions that can be treated with Esketamine?

Esketamine is FDA-approved for treatment-resistant depression and is typically combined with other therapies and should be determined by a healthcare professional for each individual’s specific condition. Whether you want to treat depression or another mental health disorder, you should always discuss this thoroughly with your healthcare practitioner.

How is Esketamine administered, and what are the potential side effects?

This treatment option is administered as a nasal spray under medical supervision. Potential side effects of the treatment may include dissociation, dizziness, and nausea. Patients need to avoid driving or operating heavy machinery for at least 8 hours after receiving Esketamine. It is also important for patients to be closely monitored when first trying out this treatment to make sure they don’t experience any significant side effects.

Does Insurance cover Esketamine, and what is the cost of treatment?

Insurance coverage for Esketamine can vary depending on the plan and diagnosis. While most insurance plans cover this treatment, you must check with your provider for specific details. 


Esketamine treatment has proven to be a game-changer in the field of mental health for depression. Its effectiveness in treating treatment-resistant depression and reducing suicide risk has brought new hope to those who have struggled to find relief through traditional methods. Furthermore, studies have shown that Esketamine does not negatively impact cognitive functioning, addressing concerns about potential side effects. While there are limitations to its use and further research is needed, there is no denying that Esketamine has become a promising treatment.

Contact us today at Memor Health to find out more about depression treatment options or to schedule an appointment.

Picture of Yvette Kaunismaki

Yvette Kaunismaki

Yvette Kaunismaki, MD, specializes in psychiatry with a holistic approach, focusing on integrating therapy and medication for women’s issues, depression, anxiety, and bipolar disorder. She emphasizes a team-based method, aiming for balanced mental health through collaborative care with experienced therapists.

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